Pengaruh Penambahan Enhancer Isopropil Miristat dan dan Propilen Glikol terhadap Penetrasi Krim Asiklovir

Acyclovir, a BCS class III drug, has high ability to fight the herpes virus but low permeability and is poorly soluble in water. In order obtain expected effect of viral infection on skin, penetration active ingredients becomes critical factor for topical treatment achieve desired concentration. This study was see adding isopropyl myristate propylene glycol as enhancers that help diffuse drug through stratum corneum. The formulation made by enhancer 8% (F1), (F2), without (F3). Physical stability acyclovir cream, including homogeneity, organoleptic, pH, viscosity, type emulsion power spread, vitro cream test with Franz diffusion cells will be observed. result preparations F1, F2, F3 had homogeneous preparation white semisolid odorless pH between 7,30-7,60, o/w, viscosity 35000-47000 cPS. cumulative amount penetrated at 226,008± 8,462 μg/cm2, while containing F1 258,059±1,730 μg/cm2 F2 268,336±0,740 respectively. presence increase more using than glycol.